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. 2021 Jun 23;22(13):6752. doi: 10.3390/ijms22136752

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Inter-experiment correlation diagram, plotting the fold changes of shared metabolites. Each dot represents 1 out of 32 shared metabolites. Metabolites that show a difference in the same direction (decrease or increase of RMA value for both sets) are highlighted by a stronger black border. Metabolites that have FDRs lower than certain thresholds are highlighted in yellow or red (comp. legend). Ornithine, Glyceric acid, and L-alpha-Aminobutyric acid all have fold changes that exceed the plot margins; they were set to a fold change of 0 for TEXUS-54, resp. 2.3 for L-alpha-Aminobutyric acid for CELLBOX-PRIME, the correct fold change was included in their label. Clusters that were identified in Figure 9 have been included in the figure by drawing colored boxes around metabolites that are in a cluster group. The plot has four different quadrants, with many metabolites in the top left quadrant with increased concentrations for TEXUS-54 and decreased concentrations for CELLBOX-PRIME, and a center that includes metabolites which do not or only slightly react to altered gravity.