Table 2.

Echocardiogram statistics for control and Tie1-cko adult mice. Measurements taken from 10-week old female control (n=3) and Tie1-cko mice (n=5). The aortic valve measurement describes the annulus dimension as viewed by transthoracic echocardiogram in the parasternal long axis view. P values were calculated using an unpaired, 2-tailed Student’s t-test represented as mean ± SD.

Parameters	Control	Tie1-cko	P value
Heart Rate (bpm)	502 ± 27.4	494 ± 15.7	0.62
Vol Syst (mm3)	17.4 ± 8.5	26.04 ± 7.1	0.14
Vol Diast (mm3)	50.6 ± 16.7	62.3 ± 10.9	0.27
Ejection Fraction (%)	67 ± 7	57.8 ± 4	0.05
Fractional Shortening (%)	36 ± 5	30.4± 2	0.05
LV Mass-corrected (mg)	60.1 ± 1	68.2 ± 5.1	0.06
AoV annular diameter (mm)	1.07 ± 0.06	1.20 ± 0.13	0.17
Ao Root (mm)	1.48 ± 0.06	1.67 ± 0.11*	0.04
Ao Valve Peak Velocity (mm/sec)	749.3 ± 103.3	876.8 ± 125.65	0.19
Ao Valve Peak Gradient (mmHg)	3 ± 1.01	2.94 ±0.98	0.94