Figure 4.

Superimposition of the three known structures of AT₁. Inactive (salmon), canonical active (green) and alternative active (cyan). TM6 and TM7 are located in the front. In the inactive structure, TM6 is remarkably bent inside the receptor, while TM7 is slightly twisted outside. The reference inactive structure of AT₁ has been chosen as PDB code 4YAY (from [99]). Canonical active and alternative active structures have been chosen as PDB code 6OS0 and 6OS1 respectively (from [96]). The figure was prepared with the PyMOL software (The PyMOL Molecular Graphics System, Version 2.5.0. Schrödinger, LLC).