Figure 7.

Positions of the cysteine 289 residue in the three known AT₁ structures. Superimposition of the three known AT₁ structures: inactive (salmon), canonical active (green) and alternative active (cyan). TM6 and TM7 are located in the front. C289 residue is indicated by arrows. The reference inactive structure of AT₁ has been chosen as PDB code 4YAY (from Zhang et al. [99]). Canonical active and alternative active structures are simulation data available in supplementary material from Suomivuori et al. [98]. The figure was prepared with the PyMOL software (The PyMOL Molecular Graphics System, Version 2.5.0. Schrödinger, LLC).