Table 2.
Univariate analysis and Cox multivariate regression model in patients with localized non-small cell lung cancer who were treated with stereotactic body radiation therapy.
| Patient Characteristics |
Univariate Model | Multivariate Model | ||||
|---|---|---|---|---|---|---|
| HR | p-Value | 95% CI | HR | p-Value | 95%CI | |
| Male gender | 1.55 | 0.26 | 0.72–3.32 | 1.35 | 0.49 | 0.58–3.15 |
| Age ≥70 years | 3.10 | 0.04 | 1.07–8.99 | 3.28 | 0.07 | 0.92–11.78 |
| Adenocarcinoma | 0.65 | 0.27 | 0.31–1.39 | 1.00 | 0.99 | 0.45–2.26 |
| G-8 score ≤14 | 3.24 | 0.03 | 1.12–9.39 | |||
| HGST score ♂ < 21 kg/♀ < 15 kg 1 | 1.64 | 0.24 | 0.72–3.72 | |||
| HGST+G-8 combination 2 | ||||||
| Fit (reference) | - | - | - | - | - | - |
| Vulnerable | 2.77 | 0.10 | 0.81–9.44 | 2.03 | 0.32 | 0.50–8.18 |
| Frail | 5.24 | 0.02 | 1.34–20.40 | 3.80 | 0.09 | 0.80–18.01 |
| ECOG Performance Status ≥2 | 1.94 | 0.08 | 0.92–4.08 | 1.12 | 0.84 | 0.37–3.40 |
| Charlson Comorbidity Index | ||||||
| 0–1 (reference) | - | - | - | - | - | - |
| 2–3 | 1.89 | 0.13 | 0.83–4.33 | 1.45 | 0.42 | 0.59–3.56 |
| >3 | 1.92 | 0.28 | 0.58–6.32 | 3.89 | 0.06 | 0.96–15.81 |
| Barthel-20 score <19 | 1.56 | 0.26 | 0.72–3.40 | 1.06 | 0.92 | 0.35–3.17 |
| CGA 3 | 0.66 | 0.28 | 0.31–1.40 | 0.70 | 0.44 | 0.28–1.75 |
G-8—Geriatric 8 screening tool, HGST—hand-grip strength test, ♂—male, ♀—female, ECOG Performance Status—Eastern Cooperative Oncology Group’s definition of performance status. 1 Hand-grip strength test measured using a Smedley Dynamometer. 2 Fit (normal G-8 and normal HGST), Vulnerable (abnormal G-8 or abnormal HGST), and Frail (abnormal G-8 and abnormal HGST). 3 Patients were randomized 1:1 to receive CGA or not upon inclusion in the previous randomized study.