FIGURE 1.

(a) CEM‐PA specific DNA enzyme selection process. The original library was fixed, the sequence was cleaved in the presence of CEM. After PCR, cleaved fragments were restored to the original full‐length library to inoculate the subsequent round of selection. A molecular beacon design was used for the DNAzyme sensor. (b) Ratio of cleavage of selection progress (C/C0). (c) The most abundant 10 DNA sequences using deep sequencing. Red letters in bold represent highly aligned PAE‐1 and PAE‐3 sequences. (d) The initial library selected in vitro. The cleavage site is at the rA junction and labeled with biotin at the 5′ end. Secondary structure of PAE‐1 and PAE‐3 DNAzymes