Table 2.
Rat ectopic and bone defect models.
| Rat Ectopic Model | ||||
|---|---|---|---|---|
| Author (Year) | Carrier | BMP Dose (µg) | Time (Weeks) | Sample Size (n) |
| Kuboki et al. (1998) | HA | 1, 2, 3, and 4 | ||
| Tsuruga et al. (1998) | HA | 4 | 1, 2, 3, and 4 | 3 |
| Alam et al. (2000) | TCP, HA, BCP | 1.5 and 10 | 2 and 4 | 3 |
| Vehof et al. (2002) | HA | 8 | 3, 5, 7, and 9 | 3 |
| Kim Chang-Sung et al. (2004) | TCP, Collagen | 5 | 2 and 8 | 10 |
| Tazaki et al. (2006) | HA | 0.5, 1, and 5 | 3 | |
| Tazaki et al. (2008) | HA, TCP | 0.5, 1, and 5 | 3 | 3 |
| Luca et al. (2010) | Chitosan/Hyaluronan hydrogel | 150 | 3 | 3, 6 |
| Reves et al. (2011) | Chitosan-nano-HA | 36 | 4 | 6 |
| Park et al. (2011) | BCP | 2.5 | 2 and 8 | 5–8 |
| Bhakta et al. (2012) | Hyaluronan-based hydrogel | 5 | 8 | 6 |
| Strobel et al. (2012) | BCP | 1.6 | 2, 4, and 6 | 6 |
| Kisiel et al. (2013) | Hyaluronan hydrogel/Fibronectin fragments | 4 | 7 | 6 |
| Ma et al. (2014) | BCP | 20 | 8 | 6 |
| Mumcuoglu et al. (2018) | Collagen-based microspheres/Alginate | 0.3, 1, and 10 | 10 | 8 |
| Lin et al. (2019) | Coralline HA | 20 | 5 | 6 |
| Rat Calvarial Defect Model | ||||
| Author (Year) | Carrier | BMP Dose ( µg) |
Time
(Weeks) |
Sample Size (n) |
| Jung et al. (2006) | TCP | 2.5 | 2 and 8 | 20 |
| Kim et al. (2011) | BCP | 50 and 250 | 2 and 8 | 20 |
| Park et al. (2011) | BCP | 2.5 | 2 and 8 | 5–8 |
| Notodihardjo et al. (2011) | HA | 10 | 4 | 5 |
| Jang et al. (2012) | BCP | 2.5, 5, 10, and 20 | 2 and 8 | 8 |
| Lee JH et al. (2013) | TCP, HA, BCP | 5 | 4 and 8 | 13 |
| Bae et al. (2017) | PCL/TCP | 5 | 4 | 7 |
| Rat Femoral Defect Model | ||||
| Author (Year) | Carrier | BMP Dose ( µg) | Time (Weeks) | Sample Size (n) |
| Chu et al. (2006) | Poly(propylene fumarate)/TCP/DCP | 10 | 6 and 15 | 4, 7 |
| Johnson et al. (2011) | Collagen, Collagen/Heparin, Heparin |
3 | 12 | 7, 9 |
| Diab et al. (2011) | PCL/Silk fibroin hydrogel | 5 | 12 | 10 |
| Lee et al. (2012) | BCP | 1000 | 4 and 8 | 6 |
| Rodriguez-Evora et al. (2013) | Segmented polyurethane/PLGA/ TCP ceramics | 1.6 and 6.5 | 12 | 9 |
| Wai-Ching et al. (2014) | Bioactive glass/DCP | 10 | 15 | 8, 9 |
| Williams et al. (2015) | Collagen | 25, 50, 75 and 100 | 8 | 8, 11 |
| Krishnan et al. (2015) | Nanofiber mesh alginate | 5 µg | 12 | 14 |