Table 3.
Rabbit segmental defect model.
| Rabbit Segmental Defect Model | |||||
|---|---|---|---|---|---|
| Author (Year) | Model | Carrier | BMP Dose (µg) | Time (Weeks) | Sample Size (n) |
| Yoneda et al. (2004) | Femur (1.5 cm) | PLA-DX-PEG/TCP | 50 | 24 | 5 |
| Yamamoto et al. (2006) | Ulna (2 cm) | Gelatin hydrogel | 17 | 6 | 3 |
| Liu et al. (2009) | Radius (1.5 cm) | Gelatin/nanoHA/Fibrin | 100 | 4, 8, and 12 | 5 |
| Luca et al. (2010) | Radius (1.5 cm) | Chitosan hydrogel/TCP | 150 | 8 | 1 (pilot) |
| Zhu et al. (2010) | Radius | nanoHA | 4, 8, and 12 | 10 | |
| Bae et al. (2011) | Ulna (1.5 cm) | PCL/fibrin | 75 | 8 | 5 |
| Fujita et al. (2011) | Ulna (2 cm) | Gelatin/TCP | 17 | 4 and 8 | 6, 10 |
| Sun-Woong et al. (2012) | Ulna (2 cm) | PCL | 15 | 12 | 6 |
| Hou et al. (2012) | Radius (1.5 cm) | Collagen, Collagen/Chitosan |
50 | 2, 4, 8, and 12 | 3, 5 |
| Choi et al. (2014) | Radius (2 cm) | Collagen, Fibrin glue |
50 | 6 and 12 | 4 |
| Wu et al. (2014) | Radius (1.5 cm) | CaP cement, Hydroxypropylmethyl cellulose/CaP cement |
50 | 2, 4, 8, and 12 | 5 |
| Yamamoto et al. (2015) | Ulna (2 cm) | Gelatin/TCP | 17 | 6 | 6 |
| Peng et al. (2016) | Femur (1 cm) | PEG-PLGA hydrogel | 5, 10, and 20 | 12 | 6 |
| Pan et al. (2017) | Femur (2 cm) | Bioglass/TCP | 20 | 4 and 8 | 5 |
| Kuroiwa et al. (2018) | Femur (2 cm) | TCP | 50 | 12 and 24 | 10 |
| Grgurevic et al. (2019) | Ulna (1.5 cm) | Autologous blood coagulum | 25, 50, and 100 | 23 | 5 |
| Huang et al. (2021) | Ulna (2 cm) | TCP | 20 | 8 | 5 |