Table 5.
Dog and sheep segmental defect model.
| Dog Segmental Defect Model | |||||
|---|---|---|---|---|---|
| Author (Year) | Model | Carrier | BMP Dose (µg) | Time (Weeks) | Sample Size (n) |
| Itoh (1998) | Ulna (2 cm) | PLGA/Gelatin | 40, 160, and 640 | 16 | 4 |
| Tuominen (2000) | Ulna (2 cm) | Coral | - | 16 and 36 | 3, 6 |
| Hu (2003) | Radius (2 cm) | HA/Collagen/PLA | - | 24 | 6 |
| Jones (2008) | Ulna (2.5 cm) | Collagen/Allograft, Collagen/BCP ceramics |
210, 430, and 650 | 12 | 6 |
| Harada (2012) | Ulna (2.5 cm) | TCP | 35, 140, 560, and 2240 | 12 | 3 |
| Minier (2014) | Ulna (2 cm) | CaP/Hydrogel | 330 | 20 | 5 |
| Sheep Segmental Defect Model | |||||
| Author (Year) | Model | Carrier | BMP Dose ( µ g) | Time (Weeks) | Sample Size (n) |
| Den Boer et al. (2003) | Tibia (3 cm) | HA | 2500 | 12 | 8 |
| Pluhar et al. (2006) | Tibia (5 cm) | Carboxymethylcellulose/Bovine collagen, Collagen | 3500 | 16 | 10 |
| Reichert et al. (2012) | Tibia (3 cm) | mPCL-TCP | 3500 | 12 and 52 | 8 |
| Cipitria et al. (2013) | Tibia (3 cm) | mPCL-TCP | 1750 and 3500 | 12 | 8 |
| Lammens et al. (2020) | Tibia (3 and 4.5 cm) | CaP ceramics | 344, 1500, and 3800 | 16 | 4, 8, 13 |