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. 2021 Jun 25;12:653110. doi: 10.3389/fimmu.2021.653110

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Copyright © 2021 Shao, Saredy, Xu, Sun, Saaoud, Drummer, Lu, Luo, Lopez-Pastrana, Choi, Jiang, Wang and Yang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The heatmap plot with customized color scales indicates that some of 11 functional groups of innate immune regulatomic genes are shared in endothelial cells infected by viruses and stimulated by DAMPs. The values of LogFC (P value <0.05) in each comparison are colored via the color scales. The datasets (Cells) in blank (N/A) indicates that differentiation expression (DE) of the gene has no statistical significance (P value ≥ 0.05) in the comparisons. The gene categories were identified by the functional annotations in the Ingenuity Pathway Analysis (IPA).