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A new working model: Endothelial cells are innate immune cells, which express innate immune regulatomic genes and regulators for trained immunity-related metabolic and epigenetic reprogramming, and play significant roles in vascular homeostasis, inflammatory cell recruitment, myelopoiesis, innate immunity, cell death, thromboembolism, cytokine storms and cardiovascular comorbidities of COVID-19 and other viral infections.
