Table 1.
The information are presented on the profiles of the 35 transcriptomic datasets deposited in NIH-NCBI-Geo Datasets database and EMBL-EBI-ArrayExpress database including 28 datasets collected from twenty-four human and four mouse endothelial cells in in vitro and ex vivo experiments, and seven datasets collected from dendritic cells and macrophages as controls.
| Conditions | Cell origin | Specific comparisons | GEO profiles | Assigned labels |
|---|---|---|---|---|
| LPS | CD14+ cells from PBMC | LPS stimulation for 24hrs | GSE22886 | a |
| IFN-g | IFN-g stimulation, IFN-g primed + stimulation, and IFN-g primed only for 24 hrs vs control | GSE1925 | b,c,d | |
| IFN-g+LPS | CD14+ cells from PBMC | IFN-g + LPS and IFN-g stimulation for 24 hrs | GSE85346 | e,f |
| ZHX2 KO | RAW264.7 Macrophage | Zhx2 null vs WT | PMID 30026271 | g |
| Virus | human umbilical vein endothelial cells (HUVECs) | influenza virus infection vs inoculation of inactivated virus | GSE59226 | 1 |
| human microvascular endothelial cells (HMECs) | wild type MERS-CoV(icMERS) infection vs mock for 0hr, 8hrs, 24hrs, 36hrs, 48hrs | GSE79218 | 2,3,4,5,6 | |
| human dermal endothelial cells (HDMECs) | isolated Kaposi's sarcoma associated herpes virus (KSHV) infection for 7 days vs uninfected |
GSE1377 | 7 | |
| LPS | human lung microvascular endothelial cells (HLMECs) | lipopolysaccharide (LPS) exposure for 4hrs, 8hrs, 24hrs | GSE5883 | 8,9,10 |
| Interferons | HUVECs | IFN-a, IFN-g, IFN-b exposure for 5 hrs | GSE3920 | 11,12,13 |
| HUVECs | Notch1 siRNA vs scrambled siRNA | GSE85987 | 14 | |
| Notch1 siRNA + IL-1b for 4 hrsvs scrambled siRNA + IL-1b | 15 | |||
| human aortic endothelial cells (HAECs) | oxPAPC treatment for 6 hrs | GSE72633 | 16 | |
| Key molecules deficiency and sterile danger signals exposuer | HACEs | LPC teratment for 18 hrs | PMID 39769317 | 18 |
| LPC + IL-35 teratmentvs | 19 | |||
| LPC for 18 hrs | ||||
| Borrelia burgdorferi infection vs unstimulation | 20 | |||
| HUVECs | INF-g stimulation vs unstimulation | GSE6092 | 21 | |
| Borrelia burgdorferi + INF-g vs unstimulation | 22 | |||
| Fibrosa human aortic valvular endothelial cells (HAVECs) | oscillatory shear exposure for 24 hr vs laminar shear exposture | GSE26953 | 23 | |
| Ventricularis HAVECs | 24 | |||
| LPS | mouse aortic endothelial cells (MAECs) | LPS exposure for 4 hrs | GSE39264 | 25 |
| ApoE KO | MAECs | From ApoE-/-mice at four weeks old vs WT mice | 26 | |
| oxLDL and Oxpapc | oxLDL, oxPAPC exposure for 4 hrs | 27,28 |