Table 3.
The receptors of cytokines, chemokines, TNFs, and IFNs are differentially expressed in HMECs infected by MERS-CoV at 12 hours (h), 24h, 36h, 48h post infection (PI) with ic-MERS virus.
| Gene symbol | Binding Ligand | logFC | |||
|---|---|---|---|---|---|
| 12(hr) | 24(hr) | 36(hr) | 48(hr) | ||
| Cytokine receptor | |||||
| IL3RA | IL-3/CSF-2/IL-5 | -0.26 | 1.01 | 0.25 | -0.35 |
| IL4R | IL-4/IL-13 | 1.03 | 0.94 | 0.73 | 0.64 |
| IL7R | IL-2/IL-4/IL-9/IL-15 | 1.96 | 1.65 | 1.17 | |
| IL13RA2 | IL-13 | -0.23 | 1.66 | 0.73 | 0.68 |
| IL15RA | IL-15/IL-2 | 2.93 | 2.54 | -0.64 | 0.95 |
| IL17RE | IL-17 | 0.84 | 1.16 | ||
| IL20RB | IL-19/IL-20/IL-24 | 1.62 | 0.54 | 0.43 | |
| IL1R1 | IL-1A/IL-1B/IL-1RA | -0.87 | -2.81 | -2.93 | -2.55 |
| IL6ST | IL-6 family | -1.01 | -2.17 | -2.39 | -1.92 |
| IL10RB | IL-10 | -0.53 | -1.53 | -1.36 | -0.60 |
| IL13RA1 | IL-4/IL-13 | -0.28 | -0.51 | -1.11 | -1.45 |
| IL17RA | IL-17A | -0.22 | -1.08 | -0.88 | |
| Chemokine receptor | |||||
| CCRL1 | CCL19/CCL21/CCL25 | 1.96 | 0.94 | ||
| CXCR4 | CXCL12 | -0.17 | -0.22 | 1.17 | |
| CCR6 | CCL20 | -0.95 | -1.21 | ||
| TNF receptor | |||||
| TNFRSF10A | TNFSF10 | 1.05 | 1.29 | 1.60 | |
| TNFRSF10B | TNFSF10 | 1.52 | 1.79 | 1.52 | 0.46 |
| TNFRSF10C | TNFSF10 | 2.56 | 3.54 | 3.22 | 1.81 |
| TNFRSF10D | TNFSF10 | 1.83 | 1.77 | 0.58 | |
| TNFRSF11A | TNFSF11 | 1.96 | 4.23 | 4.45 | 2.75 |
| TNFRSF11B | TNFSF11 | -1.00 | -1.63 | -1.00 | |
| TNFRSF12A | TNFSF12 | 0.89 | -1.02 | -0.92 | |
| CD40 | CD40L | -0.31 | -1.80 | -1.82 | -1.05 |
| TNFRSF4 | OX40L | 0.44 | -1.18 | -1.15 | -1.40 |
| TNFRSF14 | TNFSF14 | 0.55 | -0.59 | -1.76 | |
| TNFRSF19 | TNFSF19 | 0.35 | -1.09 | -0.71 | -0.51 |
| TNFRSF25 | TNFSF25 | -0.48 | -1.24 | -0.82 | -0.25 |
| IFN receptor | |||||
| IFNGR2 | IFNG | 0.53 | 1.36 | 1.27 | 0.71 |
| IFNAR1 | IFNA | -0.57 | -1.12 | -1.03 | |
| IFNGR1 | IFNG | -1.07 | -1.40 | -0.72 | |