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Combined with PZ-PSAD, (a) TRUS and (b) mpMRI can be more efficient in PCa diagnosis and help patients avoid unnecessary prostate biopsy and missed diagnosis. TRUS: transrectal ultrasound; mpMRI: multiparameter magnetic resonance imaging; PZ-PSAD: peripheral zone prostate-specific antigen density; PCa: prostate cancer; Bx: transrectal systematic 12-core prostate biopsy; (−): negative; (+): positive; PZ-PSAD (−): PZ-PSAD <0.258 ng ml−2; PZ-PSAD (+): PZ-PSAD ≥0.258 ng ml−2.
