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. Author manuscript; available in PMC: 2022 Jul 6.
Published in final edited form as: Cell Metab. 2021 Jul 6;33(7):1293–1306. doi: 10.1016/j.cmet.2021.06.006

Figure 2. Ceramide and S1P are critical links in the development of metabolic disease.

Figure 2.

Multiple factors associated with increased susceptibility to metabolic dysfunction influence the synthesis of ceramides and S1P. Subsequent derangements in ceramide/S1P levels have significant consequences to glucose and lipid homeostasis in metabolic tissues and the heart and vasculature systems.