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. Author manuscript; available in PMC: 2022 Jul 6.
Published in final edited form as: Cell Metab. 2021 Jul 6;33(7):1293–1306. doi: 10.1016/j.cmet.2021.06.006

Figure 5. S1P/S1PR signaling in inflammation and metabolic dysregulation.

Figure 5.

(A) Endothelial S1PRs influence inflammation and increase vasodilation through eNOS activation, counteracting effects mediated by ceramides. (B) In macrophages, intracellular S1P enhances degradation of stored lipids, while S1P/S1PR signals block apoptosis and increase ABCA1-mediated cholesterol export. White boxes highlight the sphingolipid biosynthetic enzymes shown to affect metabolic outcomes when altered in vivo.