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. Author manuscript; available in PMC: 2021 Sep 24.
Published in final edited form as: Nature. 2021 Mar 24;592(7855):623–628. doi: 10.1038/s41586-021-03365-x

Extended Data Fig. 2 |. Hydrogen-deuterium exchange mass spectrometry (HDX-MS) of H1-foldon trimer and H1-I53_dn5 nanoparticle.

Extended Data Fig. 2 |

a, Amino acid sequence of H1 ectodomain expressed as a genetic fusion to both foldon and I53_dn5B. Underlined sequences correspond to peptides analyzed by HDX-MS. b, Hydrogen-deuterium exchange percentages after 20 h for both samples mapped onto the structure of H1 HA (PDB 3LZG). c, Kinetics of hydrogen-deuterium exchange for both samples at multiple timepoints up to 20 h. *, peptides where a negative percent exchange was corrected to zero (< 2% magnitude correction); **, peptides that were missing a replicate at the 30 min timepoint.