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Flowchart for selecting patients for a plan comparison and PT, respectively. For each toxicity endpoint, the maximum ΔNTCP (ΔNTCPmax) has to be calculated first by the following equation: ΔNTCPmax = [NTCP − PHOTONS] − [NTCPmin − PROTONS], in which, NTCPmin − PROTONS is the NTCP value, assuming that with protons, the dose to all DVH parameters in the model can be reduced to zero. Abbreviations: DVH, dose-volume histogram; NTCP, Normal Tissue Complication Probability; PT, proton therapy.
