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. 2021 Jul 9;16(7):e0254334. doi: 10.1371/journal.pone.0254334

Table 1. Selected papers.

Author Title IC topic-of-interest Model Aspects of complexity Optimization Time frame
Alonge et al. 2017 [37] Improving health systems performance in low- and middle-income countries: a system dynamics model of the pay-for-performance initiative in Afghanistan. Pay for performance incentive scheme SD ° Dynamism
° Soft variables
° Interaction
‘What if’; ‘How to’ scenarios 5 to 8 years
Ansah et al. 2016 [38] Projecting the effects of long-term care policy on the labor market participation of primary informal family caregivers of elderly with disability: insights from a dynamic simulation model. Evaluating care management and interventions of chronic conditions—Performance evaluation of community health SD ° Dynamism
° Influence of historical occurrence
° Interaction
‘What if’ scenarios 17 years
Comans et al. 2017 [39] The development and practical application of a simulation model to inform musculoskeletal service delivery in an Australian public health service Health facility operations simulation—Planning Health force DES ° Individualization
° Influence of historical occurrence
° Interference
° Interaction
‘What if’ scenarios 5 years
Cooper et al. 2008 [40] Use of a coronary heart disease simulation model to evaluate the costs and effectiveness of drugs for the prevention of heart disease Evaluating care management and interventions of chronic conditions. DES ° Individualization
° Influence of historical occurrence
° Interference
° Simultaneity of events
° Interaction
° Dynamism
‘What if’ scenarios 20 years
de Andrade et al. 2014 [41] System Dynamics Modeling in the Evaluation of Delays of Care in ST-Segment Elevation Myocardial Infarction Patients within a Tiered Health System. Evaluating care management and interventions of chronic conditions. SD ° Dynamism
° Interaction
° Influence of historical occurrence
‘What if’ scenarios One care case: ~4hr
Fialho et al. 2011 [42] Using discrete event simulation to compare the performance of family health unit and primary health care center organizational models in Portugal. Performance evaluation of community health DES ° Individualization
° Influence of historical occurrence
° Interference
° Interaction
° Dynamism
‘What if’; ‘How to’ scenarios 1 week (1/52 year)
Gao et al. 2013 [43] Tripartite hybrid model architecture for investigating health and cost impacts and intervention tradeoffs for diabetic end-stage renal disease Evaluating care management and interventions of chronic conditions. Hybrid ° Dynamism
° Soft Variables
° Intelligent Adaptation
° Simultaneity of events
° Influence of historical occurrences
° Interaction
° Individualization
‘What if’ scenarios 1 year
Getsios et al. 2013 [44] Smoking cessation treatment and outcomes patterns simulation: a new framework for evaluating the potential health and economic impact of smoking cessation interventions. Tobacco harm policies. Market Control and Interventions DES ° Individualization
° Influence of historical occurrence
° Interaction
° Dynamism
‘What if’ scenarios Lifetime (since start smoking)
Goldman et al. 2004 [45] Projecting long-term impact of modest sodium reduction in Los Angeles County Evaluation of Public health intervention Micro ° Individualization
° Influence of historical occurrence
° Interaction
‘What if’; ‘How to’ scenarios 45 years*
Günal et al. 2011 [46] DGHPSIM: Generic Simulation of Hospital Performance Health facility operations simulation DES ° Individualization
° Interference
° Interaction
° Dynamism
° Influence of historical occurrence
‘What if’; ‘How to’ scenarios 2 years
Hill et al. 2017 [47] A system dynamic modeling approach to assess the impact of launching a new nicotine product on population health outcomes. Tobacco harm policies. Market Control and Interventions SD ° Dynamism
° Soft variables
° Interaction
‘What if’ scenarios 50 years
Homer et al. 2010 [48] Simulating and Evaluating Local Interventions to Improve Cardiovascular Health Evaluating care management and interventions of chronic conditions. SD ° Dynamism
° Soft variables
° Interaction
‘What if’ scenarios 50 years
Jones et al. 2006 [49] Understanding diabetes population dynamics through simulation modeling and experimentation. Diabetes Population Dynamics SD ° Dynamism
° Soft variables
° Interaction
‘What if’ scenarios 46 years
Kalton et al. 2016 [50] Multi-Agent-Based Simulation of a Complex Ecosystem of Mental Health Care. Health facility operations simulation ABM ° Individualization
° Simultaneity of events
° Influence of historical occurrence
° Interaction
° Emergence
° Dynamism
‘What if’; ‘How to’ scenarios 3 years
Kang et al. 2018 [51] A system dynamic approach to planning and evaluating interventions for chronic disease management Evaluating care management and interventions of chronic conditions. SD ° Dynamism
° Influence of historic occurrences
° Interaction
° Soft variables
‘What if’; ‘How to’ scenarios 10 years
Kotiadis 2006 [52] Extracting a conceptual model for a complex integrated system in health care Health facility operations simulation DES ° Individualization
° Interaction
° Interference
‘What if’; ‘How to’ scenarios 5 months
Laurence et al. 2016 [53] Improving the planning of the GP workforce in Australia: a simulation model incorporating work transitions, health needs, and service usage. Planning Health force Markov ° Interaction ‘What if’; ‘How to’ scenarios 10 years
Lay-Yee et al. 2015 [54] Determinants and disparities: a simulation approach to the case of child health care. Performance evaluation of community health Micro ° Individualization
° Influence of historical occurrence
° Dynamism
° Interaction
‘What if’ scenarios 10 years
Lebcir et al. 2017 [55] A discrete event simulation model to evaluate the use of community services in the treatment of patients with Parkinson’s disease in the United Kingdom. Performance evaluation of community health DES ° Individualization
° Influence of historical occurrence
° Interference
° Interaction
° Dynamism
° Simultaneity of events
‘What if’; ‘How to’ scenarios 3 years
Levy et al. 2016 [56] Estimating the Potential Impact of Tobacco Control Policies on Adverse Maternal and Child Health Outcomes in the United States Using the SimSmoke Tobacco Control Policy Simulation Model. Tobacco harm policies. Market Control and Interventions Markov ° Interaction
° Influence of historical events
‘What if’ scenarios 50 years
Loyo et al. 2013 [57] From model to action: using a system dynamics model of chronic disease risks to align community action. Evaluating care management and interventions of chronic conditions. SD ° Dynamism
° Soft variables
° Interaction
‘What if’ scenarios 30 years
Matta et al. 2007 [58] Evaluating multiple performance measures across several dimensions at a multi-facility outpatient center Performance measures evaluation DES ° Individualization
° Interference
° Interaction
° Dynamism
‘What if’; ‘How to’ scenarios 1 working day
Milstein et al. 2010 [59] Analyzing national health reform strategies with a dynamic simulation model. National Health Reform Evaluation SD ° Dynamism
° Soft variables
° Interaction
‘What if’ scenarios 25 years
Nianogo et al. 2018 [60] Impact of Public Health Interventions on Obesity and Type 2 Diabetes Prevention: A Simulation Study. Evaluation of Public health intervention ABM ° Individualization
° Simultaneity of events
° Influence of historical occurrence
° Interaction
° Emergence
° Intelligent Adaptation
‘What if’ scenarios Adult life
Norouzzadeh et al. 2015 [61] Simulation Modeling to Optimize Health Care Delivery in an Outpatient Clinic Health facility operations simulation DES ° Individualization
° Interference
° Interaction
° Dynamism
‘What if’; ‘How to’ scenarios 2 years
Oh et al. 2016 [62] Use of a simulation-based decision support tool to improve emergency department throughput Health facility operations simulation DES ° Individualization
° Interference
° Interaction
° Dynamism
‘What if’; ‘How to’ scenarios 2.5 years
Rashwan et al. 2015 [63] Modeling behavior of nurses in a clinical medical unit in a university hospital: Burnout implications Planning Health force SD ° Dynamism
° Soft variables
° Interaction
‘What if’; ‘How to’ scenarios 1 working day
Rejeb et al. 2018 [64] Performance and cost evaluation of health information systems using micro-costing and discrete-event simulation. Evaluation of Information System DES ° Individualization
° Influence of historical occurrence
° Interference
° Interaction
° Dynamism
° Simultaneity of events
‘What if’; ‘How to’ scenarios 1 to 5 years
Sugiyama et al. 2017 [65] Construction of a simulation model and evaluation of the effect of potential interventions on the incidence of diabetes and initiation of dialysis due to diabetic nephropathy in Japan. Evaluating care management and interventions of chronic conditions. SD ° Dynamism
° Influence of historic occurrences
° Interaction
‘What if’ scenarios 35 years
Vataire et al. 2014 [66] Core discrete event simulation model for the evaluation of health care technologies in major depressive disorder. Evaluating care management and interventions of chronic conditions. DES ° Individualization
° Influence of historical occurrence
° Interaction
‘What if’ scenarios 1 to 5 years

* The model has been used in several projects and the time provided corresponds the one used most recently by Vidyanti et al. 2015 [67]