The influence of formulation composition of F1-F14 (Smix ratio, and %concentration of Smix) and the ultrasonication process conditions (ultrasonication time) on the mean droplet size and PdI. (a) Mean droplet size of NE prepared by ultrasonication at an amplitude of 40% at a different time interval (3, 5, and 10 min) with different Smix ratios (1:1, 2:1, and 3:1) and Smix concentration at 30, and 40%. (b) PdI of NE prepared by ultrasonication at an amplitude of 40% at a different time interval (3, 5, and 10 min) with different Smix ratios (1:1, 2:1, and 3:1) and Smix concentration at 30, and 40%. † represents formulation compositions as %oil, %Smix, and %water are 10%, 30%, and 60% respectively while * represents formulation compositions as % oil, % Smix, and %water are 10%, 40%, and 50%, respectively.