Table 1.
Characterization of selected TMQ-loaded NE for thermodynamic stability, droplet size distribution, zeta potential, % drug content, and viscosity.
| Formulation Code |
Thermodynamic Stability | Mean Droplet Size (nm) |
PdI | Zeta Potential (mV) |
Drug Content (%) | Viscosity (mPas) |
||
|---|---|---|---|---|---|---|---|---|
| Heating Cooling Cycle | Centrifugation Study | Freeze-Thaw Cycle | ||||||
| F8 | √ | √ | √ | 48.45 ± 0.74 | 0.052 ± 0.004 | −29.5 ± 0.30 | 99.32 ± 0.119 | 77.81 ± 1.55 |
| F11 | √ | √ | √ | 64.22 ± 0.94 | 0.203 ± 0.01 | −30.6 ± 0.40 | 99.14 ± 0.112 | 74.91 ± 1.74 |
| F12 | √ | √ | √ | 94.67 ± 0.71 | 0.26 ± 0.03 | −30.5 ± 0.30 | 98.74 ± 0.445 | 71.04 ± 1.02 |
| F14 | √ | √ | √ | 40.02 ± 0.83 | 0.542 ± 0.05 | −26.7 ± 0.26 | 99.09 ± 0.49 | 88.82 ± 1.27 |
| F18 | √ | √ | √ | 99.66 ± 1.43 | 0.428 ± 0.017 | −28.9 ± 0.25 | 99.04 ± 0.258 | 85.38 ± 2.25 |