TABLE 1.

Definitional Variation in MME by Type of Pain Medication

	Average Daily MME		Daily MME, Median (IQR)
Definition	California	Florida	California	Florida
All patients on opioid analgesics (mg)
Total days supply	33	39	25 (18, 40)	30 (20, 45)
On-therapy days	38	46	25 (18, 40)	30 (20, 46)
Fixed observation window	17	23	3.3 (1.1, 13.9)	4.2 (1.2, 19.8)
Maximum daily dose	52	65	30 (20, 50)	33 (20, 60)
No. patients	2,430,870	1,485,591	2,430,870	1,485,591
Average on-therapy days (d)	30	34	13 (5, 56)	17 (3, 69)
Immediate-release only (mg)
Total days supply	30	34	24 (17, 38)	30 (19, 40)
On-therapy days	31	35	25 (18, 38)	30 (19, 43)
Fixed observation window	10	13	2.7 (1.1, 10.2)	3.3 (1.1, 13.0)
Maximum daily dose	40	45	30 (20, 45)	30 (20, 50)
No. patients	2,273,028	1,338,828	2,273,028	1,338,828
Average on-therapy days (d)	27	30	10 (5, 46)	12 (3, 58)
Extended-release only (mg)
Total days supply	90	87	60 (30, 120)	60 (30, 120)
On-therapy days	104	97	62 (31, 121)	63 (32, 120)
Fixed observation window	73	67	42 (15, 90)	41 (14, 90)
Maximum daily dose	154	143	90 (45, 180)	90 (55, 180)
No. patients	40,038	26,039	40,038	26,039
Average on-therapy days (d)	61	60	75 (30, 89)	73 (29, 89)
Extended-release and immediate-release (mg)
Total days supply	74	83	55 (38, 90)	66 (44, 108)
On-therapy days	144	160	100 (63, 172)	123 (75, 210)
Fixed observation window	123	133	82 (42, 151)	98 (51, 181)
Maximum daily dose	251	268	173 (105, 300)	200 (120, 345)
No. patients	117,804	120,724	117,804	120,724
Average on-therapy days (d)	74	74	88 (63, 92)	88 (67, 92)

IQR indicates interquartile range; MME, milligrams of morphine equivalents.