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Correlation between “direct” and “surrogate” ACE2 or POP activity. Results from each participant are shown and represent the direct serum ACE2 activity (A) and POP activity (B) plotted against “surrogate” enzymatic activities using the corresponding plasma ANG-(1–7):ANG II peptide ratio. Each dot represents the paired corresponding enzymatic activity and peptide ratio for an individual patient. ACE2, angiotensin-converting enzyme 2; ANG, angiotensin; POP, prolyloligopeptidase.
