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. Author manuscript; available in PMC: 2021 Jul 9.
Published in final edited form as: Cell Rep. 2021 Jun 29;35(13):109303. doi: 10.1016/j.celrep.2021.109303

Figure 3. TLR2 activation alters the transcriptional program of differentiating Th17 cells.

Figure 3.

(A) Graphical representation of genes upregulated (red) or downregulated (blue) in PAM3CSK4-activated Th17(β) cells compared to non-PAM-treated Th17 cells by RNA sequencing. n = 2 biological replicates per group.

(B) Heatmap comparing expression levels of selected genes from naive CD4+, Th17(β) cells, and Th17(β) cells stimulated with PAM3CSK4. *p < 0.01 (FDR).

(C) Gene set enrichment analysis of TLR2-stimulated Th17 cells compared to Th17 cells generated with IL-1, IL-6, and IL-23. Normalized enrichment score (NES) and statistical significance (FDR) are listed.