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. Author manuscript; available in PMC: 2021 Jul 9.
Published in final edited form as: Cell Rep. 2021 Jun 29;35(13):109303. doi: 10.1016/j.celrep.2021.109303

Figure 7. Enforced IPCEF expression in Th17 cells reduces Th17 migration and EAE disease.

Figure 7.

(A) EAE incidence in mice following transfer of CD4+RV+ cells expanded with PAM3CSK4 and transduced with either RV-Mock or RV-IPCEF. ***p < 0.001 (Fisher’s exact test).

(B) Mean clinical scores (+SDs) of the mice described in (A) up to the experimental endpoint. ****p < 0.0001 (2-way ANOVA).

(C and D) Mean cell numbers (C) and (D) frequencies of CD4+, CD11B+, CD4+IL-17+, CD4+IFN-γ+, and CD4+IL-17+IFN-γ+ cells isolated from the CNS as assessed by flow cytometry and pooled (means ± SDs). *p < 0.01, ****p < 0.0001 (2-way ANOVA).

(E and F) Mean (+SDs) cell numbers (E) and (F) frequencies of the same populations identified in spleens of EAE mice. Data are representative of 3 independent experiments.