Table 3.
Changes in NETosis markers and laboratory measurements after transplantation.
| Transplantation | |||
| Variables | Pre n = 95 | Post n = 95 | P-value |
| NETosis markers | |||
| H3cit, ng/mL | 13.4 [5.8–27.3] | 22.7 [8.5–49.4] | .0008 |
| PAD4, ng/mL | 2.8 [1.2–6.8] | 4.5 [1.6–8.6] | .1544 |
| Laboratory measurements | |||
| Hb, g/dL | 10.2 ± 2.2 | 13.0 ± 1.7 | <.0001 |
| WBC count, x 103/μL | 6.4 [5.4–9.1] | 6.2 [4.6–7.8] | .030 |
| Neutrophils x 103/μL | 4.0 [3.2–6.2] | 3.8 [3.0–4.8] | .026 |
| Lymphocytes, x 103/μL | 1.3 [0.9–1.9] | 1.4 [0.9–2.1] | .022 |
| Platelets, x 103/μL | 227 [193–274] | 267 [230–314] | <.0001 |
| N/L ratio | 20.3 ± 52.3 | 3.7 ± 3.3 | .033 |
| P/L ratio | 0.5 ± 1.1 | 0.3 ± 0.3 | .806 |
| Urea, mmol/L | 20 [16–25] | 7 [6–9] | <.0001 |
| sCr, μmol/L | 1085 [714–1353] | 106 [84–137] | <.0001 |
| eGFR, mL/min/1.73 m2 | 4.6 [3.4–6.3] | 75.8 [56.9–93.6] | <.0001 |
| Glucose, mg/dL | 95 [83–107] | 87 [81–96] | .002 |
Data are expressed as mean ± standard error of the mean or median [IQR]. The P-values for continuous variables were calculated with paired-samples t-test (parametric comparisons) or the Wilcoxon Rank Test (non-parametric comparisons). P values <.05 are considered statistically significant. eGFR = estimated glomerular filtration rate, H3cit = citrullinated histone H3, L = lymphocyte, N = neutrophil, P = platelet, PAD4 = Peptidyl arginine deiminase 4, sCr = serum creatinine, WBC = white blood cells.