Table 1.

Basic characteristics of the included studies.

Study	Year	Region	Histological type	Detection method	Cut-off value	Case (n)	High expression (n)	High expression (%)	Follow-up (mo)	NOS score	Quality	Outcome	Analysis
Chen	2019	Asian	colorectal cancer	qRT-PCR	mean	79	43	54.4	60	7	High	OS	MA
Fei	2018	Asian	osteosarcoma	qRT-PCR	mean	48	26	54.2	60	7	High	OS	UA
Fu	2017	Asian	pancreatic cancer	qRT-PCR	NA	81	41	50.6	60	6	High	OS	UA
Gao	2015	Asian	pancreatic cancer	qRT-PCR	NA	61	31	50.8	45	4	Low	OS	UA
Hou	2018	Asian	breast cancer	qRT-PCR	mean	94	35	37.2	60	7	High	OS	UA
Li	2017	Asian	HCC	qRT-PCR	median	88	44	50.0	60	7	High	OS/DFS	UA
Liu	2017	Asian	ESCC	qRT-PCR	NA	120	64	53.3	60	6	High	OS/DFS	UA/MA
Qu	2017	Asian	NSCLC	qRT-PCR	median	229	113	49.3	60	7	High	OS/DFS	UA/MA
Shang	2018	Asian	ESCC	qRT-PCR	NA	96	–	–	50	4	Low	OS	UA
Shi	2017	Asian	renal cancer	qRT-PCR	NA	36	18	50.0	24	6	High	OS	UA
Wang	2016	Asian	gallbladder cancer	qRT-PCR	NA	30	14	46.7	36	6	High	OS	UA
Xia	2017	Asian	NSCLC	qRT-PCR	median	40	–	–	60	4	Low	OS	UA
Zhou	2016	Asian	colon cancer	qRT-PCR	median	60	32	53.3	80	8	High	OS/DFS	UA/MA
Zou	2016	Asian	gastric cancer	qRT-PCR	median	135	68	50.4	120	7	High	OS	UA/MA

DFS = disease-free survival, ESCC = esophageal squamous cell carcinoma, HCC = hepatocellular cancer, MA = multivariate analysis, NA = not available, NOS = Newcastle–Ottawa scale, NSCLC = non-small-cell lung cancer, OS = overall survival, qRT-PCR = quantitative real-time PCR, UA = univariate analysis.