Table 4.
The subgroups analysis for lincRNA-ROR and DFS in cancer patients.
Pooled Data | Test for Heterogeneity | ||||||||
Subgroups | Number of Studies | Case (n) | High expression (n) | High expression (%) | HR | 95% CI | P-value | P-value | I2 (%) |
Univariate analysis | |||||||||
Histological type | |||||||||
Digestive cancer | 3 | 268 | 140 | 52.2 | 2.96 | 1.24–7.07 | .015 | .001 | 86.2 |
Other cancer | 1 | 229 | 113 | 49.3 | 1.82 | 1.25–2.65 | .002 | – | – |
Case (n) | |||||||||
< 100 | 2 | 148 | 76 | 51.4 | 4.38 | 1.28–15.01 | .019 | .015 | 83.0 |
≥ 100 | 2 | 349 | 177 | 50.7 | 1.66 | 1.30–2.13 | <.001 | .531 | 0.0 |
Follow-up (mo) | |||||||||
≤ 60 | 3 | 437 | 221 | 50.6 | 1.76 | 1.40–2.21 | <.001 | .426 | 0.0 |
> 60 | 1 | 60 | 32 | 53.3 | 8.51 | 3.73–19.42 | < .001 | – | – |
Multivariate analysis | |||||||||
Histological type | |||||||||
Digestive cancer | 2 | 180 | 96 | 53.3 | 3.45 | 1.97–6.04 | <.001 | .295 | 8.9 |
Other cancer | 1 | 229 | 113 | 49.3 | 3.42 | 1.59–7.36 | .002 | – | – |
Case (n) | |||||||||
< 100 | 1 | 60 | 32 | 53.3 | 5.64 | 1.92–16.57 | .002 | – | – |
≥ 100 | 2 | 349 | 177 | 50.7 | 3.10 | 1.94–4.94 | <.001 | .751 | 0.0 |
Follow-up (mo) | |||||||||
≤ 60 | 2 | 349 | 177 | 50.7 | 3.10 | 1.94–4.94 | <.001 | .751 | 0.0 |
> 60 | 1 | 60 | 32 | 53.3 | 5.64 | 1.92–16.57 | .002 | – | – |
CI = confidence interval, DFS = disease-free survival, HR = hazard ratio, LincRNA-ROR = Large intergenic noncoding RNA regulator of reprogramming.