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. 2021 Jul 9;100(27):e26535. doi: 10.1097/MD.0000000000026535

Table 4.

The subgroups analysis for lincRNA-ROR and DFS in cancer patients.

Pooled Data Test for Heterogeneity
Subgroups Number of Studies Case (n) High expression (n) High expression (%) HR 95% CI P-value P-value I2 (%)
Univariate analysis
Histological type
 Digestive cancer 3 268 140 52.2 2.96 1.24–7.07 .015 .001 86.2
 Other cancer 1 229 113 49.3 1.82 1.25–2.65 .002
Case (n)
 < 100 2 148 76 51.4 4.38 1.28–15.01 .019 .015 83.0
 ≥ 100 2 349 177 50.7 1.66 1.30–2.13 <.001 .531 0.0
Follow-up (mo)
 ≤ 60 3 437 221 50.6 1.76 1.40–2.21 <.001 .426 0.0
 > 60 1 60 32 53.3 8.51 3.73–19.42 < .001
Multivariate analysis
Histological type
 Digestive cancer 2 180 96 53.3 3.45 1.97–6.04 <.001 .295 8.9
 Other cancer 1 229 113 49.3 3.42 1.59–7.36 .002
Case (n)
 < 100 1 60 32 53.3 5.64 1.92–16.57 .002
 ≥ 100 2 349 177 50.7 3.10 1.94–4.94 <.001 .751 0.0
Follow-up (mo)
 ≤ 60 2 349 177 50.7 3.10 1.94–4.94 <.001 .751 0.0
 > 60 1 60 32 53.3 5.64 1.92–16.57 .002

CI = confidence interval, DFS = disease-free survival, HR = hazard ratio, LincRNA-ROR = Large intergenic noncoding RNA regulator of reprogramming.