Table 1.
GO analysis in BP and KEGG pathway analysis of reproductive toxicity of Tripterygium wilfordii, including the top 5 terms selected according to the P value.
| Term | Description | Count | P-value |
| Top 5 BPs | |||
| GO:0042493 | response to drug | 57 | 1.25E-29 |
| GO:0035235 | ionotropic glutamate receptor signaling pathway | 18 | 1.14E-21 |
| GO:0045893 | positive regulation of transcription, DNA-templated | 61 | 6.18E-21 |
| GO:0010628 | positive regulation of gene expression | 44 | 6.53E-21 |
| GO:0045944 | positive regulation of transcription from RNA polymerase II promoter | 85 | 3.28E-20 |
| Top 5 KEGG pathways | |||
| hsa04080 | Neuroactive ligand-receptor interaction | 70 | 2.21E-27 |
| hsa05033 | Nicotine addiction | 26 | 6.59E-22 |
| hsa04024 | cAMP signaling pathway | 46 | 2.21E-16 |
| hsa04020 | Calcium signaling pathway | 41 | 2.54E-14 |
| hsa05031 | Amphetamine addiction | 25 | 4.71E-14 |
BPs = biological processes, GO = gene ontology, KEGG = Kyoto Encyclopedia of Genes and Genomes.