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. 2021 Jul 9;100(27):e26197. doi: 10.1097/MD.0000000000026197

Table 2.

Top 5 genes with the highest degree of interaction in the PPI network.

Gene ID Degree Closeness Centrality Betweenness Centrality
TP53 57 0.42209073 0.14499223
INS 55 0.42928786 0.13712094
IL6 51 0.42714571 0.08306111
AGT 49 0.39194139 0.03955276
ADCY3 43 0.35489221 0.03243746

ADCY3 = adenylate cyclase 3, AGT = Angiotensinogen, INS = insulin, IL6 = interleukin-6, PPI = protein-protein interaction, TP53 = tumor protein 53.