Table 4.
Enriched GO terms and KEGG pathways of module 1.
| Term | Name | Count | P value | Genes |
| BPs | ||||
| GO:0019229 | Regulation of vasoconstriction | 5 | 4.43E-09 | BDKRB2, ADRA2C, ADRA2B, ADRA2A, AGT |
| GO:0007186 | G-protein coupled receptor signaling pathway | 11 | 5.44E-09 | CX3CR1, CHRM2, C5, GPER1, PTGER3, BDKRB2, ADRA2C, ADRA2B, ADRA2A, AGT, PF4 |
| GO:0006954 | Inflammatory response | 8 | 7.25E-08 | C5, ANXA1, CNR2, GPER1, PTGER3, BDKRB2, ADORA1, PF4 |
| MFs | ||||
| GO:0004938 | Alpha2-adrenergic receptor activity | 3 | 3.22E-06 | ADRA2C, ADRA2B, ADRA2A |
| GO:0051379 | Epinephrine binding | 3 | 1.61E-05 | ADRA2C, ADRA2B, ADRA2A |
| GO:0008144 | Drug binding | 4 | 6.82E-05 | CHRM2, CNR1, DRD2, DRD4 |
| KEGG pathways | ||||
| hsa04080 | Neuroactive ligand-receptor interaction | 12 | 3.71E-12 | CHRM2, CNR2, CNR1, ADORA3, PTGER3, BDKRB2, ADORA1, DRD2, ADRA2C, ADRA2B, ADRA2A, DRD4 |
| hsa04022 | cGMP-PKG signaling pathway | 7 | 1.34E-06 | ADORA3, BDKRB2, ADORA1, ADCY3, ADRA2C, ADRA2B, ADRA2A |
| hsa04024 | cAMP signaling pathway | 5 | 0.001180424 | CHRM2, PTGER3, ADORA1, ADCY3, DRD2 |
BPs = biological processes, KEGG = Kyoto Encyclopedia of Genes and Genomes, MFs = molecular functions.