TABLE II.
The CC statistics of each dataset are analyzed with different data processing choices. The diffuse map generated by each processing method was evaluated with five CC metrics: CCFriedel, CCLaue, CC1/2, CCRep, and CCLLM (anisotropic ADP model). Method A (standard processing pipeline) contains real CC values of each dataset up to 1.4 Å, while other methods (B)–(D) are filled with relative CC changes compared to those in method A. Cells in (B)–(D) are colored with four different colors depending on the relative changes. A cell is colored as white if the relative CC change is ±0.00 and as light blue/red if CC increases/decreases by less than 0.1; otherwise, it will be colored as dark blue/red.
| Sample | WT-1 | WT-2 | WT-3 | G150A-1 | G150A-2 | G150A-3 | G150T-1 | G150T-2 | G150T-3 |
|---|---|---|---|---|---|---|---|---|---|
| A. Standard data processing pipeline | |||||||||
| CCFriedel | 0.93 | 0.91 | 0.91 | 0.93 | 0.91 | 0.91 | 0.91 | 0.92 | 0.94 |
| CCLaue | 0.90 | 0.87 | 0.87 | 0.88 | 0.86 | 0.85 | 0.86 | 0.88 | 0.91 |
| CC1/2 | 0.85 | 0.78 | 0.81 | 0.81 | 0.76 | 0.77 | 0.82 | 0.84 | 0.89 |
| CCRep | 0.86 | 0.84 | 0.85 | 0.82 | 0.81 | 0.82 | 0.88 | 0.87 | 0.89 |
| CCLLM | 0.70 | 0.71 | 0.67 | 0.70 | 0.68 | 0.73 | 0.76 | 0.75 | 0.80 |
| B. Standard pipeline without non-crystal background image subtraction | |||||||||
| CCFriedel | −0.01 | −0.01 | −0.02 | −0.01 | −0.03 | −0.02 | −0.03 | −0.02 | −0.02 |
| CCLaue | −0.01 | −0.03 | −0.02 | −0.02 | −0.03 | −0.03 | −0.03 | −0.04 | −0.02 |
| CC1/2 | −0.02 | −0.06 | −0.04 | −0.04 | −0.07 | −0.06 | −0.06 | −0.06 | −0.03 |
| CCRep | −0.03 | −0.05 | −0.05 | −0.08 | −0.08 | −0.05 | −0.03 | −0.05 | −0.03 |
| CCLLM | −0.01 | −0.02 | −0.04 | −0.03 | −0.06 | −0.02 | −0.04 | −0.03 | −0.02 |
| C. Standard pipeline without the polarization correction | |||||||||
| CCFriedel | +0.04 | +0.04 | +0.04 | +0.03 | +0.05 | +0.04 | +0.03 | +0.03 | +0.02 |
| CCLaue | +0.05 | −0.02 | +0.04 | −0.01 | +0.07 | −0.03 | +0.03 | −0.11 | +0.03 |
| CC1/2 | +0.08 | −0.06 | +0.08 | −0.06 | +0.13 | −0.11 | +0.02 | −0.19 | +0.04 |
| CCRep | −0.13 | −0.32 | −0.27 | −0.58 | −0.31 | −0.32 | −0.16 | −0.35 | −0.15 |
| CCLLM | −0.17 | −0.14 | −0.27 | −0.23 | −0.33 | −0.16 | −0.18 | −0.09 | −0.19 |
| D. Standard pipeline without the radial profile variance removal step | |||||||||
| CCFriedel | −0.01 | −0.01 | −0.02 | −0.02 | −0.01 | −0.03 | −0.02 | −0.03 | −0.00 |
| CCLaue | −0.02 | −0.06 | −0.01 | −0.05 | −0.10 | −0.07 | −0.03 | −0.04 | −0.03 |
| CC1/2 | −0.04 | −0.11 | −0.03 | −0.09 | −0.18 | −0.15 | −0.05 | −0.07 | −0.04 |
| CCRep | −0.05 | −0.08 | −0.11 | −0.04 | −0.02 | −0.04 | −0.01 | −0.02 | −0.01 |
| CCLLM | +0.01 | −0.01 | +0.00 | −0.01 | −0.01 | −0.06 | −0.01 | −0.04 | −0.01 |