Figure 2.

An overview of the potential targets of β-cell-specific imaging probes. The identification of ideal probe targets highly specific to β cells is essential for realizing β-cell imaging. The various molecules whose expression is observed specifically in β cells have been explored. SUR1, glucose transporter 2 (GLUT-2), voltage-dependent calcium channel (VDCC), G protein-coupled receptors (GPRs), D2 and D3 dopamine receptors, serotonergic system, vesicular monoamine transporter 2 (VMAT2), and GLP-1 receptors have been reported as leading potential probe targets. K^ATP channel, ATP-sensitive potassium channel; 5-HT receptor, 5-hydroxytryptamine receptor.