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. 2021 Jun 25;12:714348. doi: 10.3389/fendo.2021.714348

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Copyright © 2021 Murakami, Fujimoto and Inagaki

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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An ¹¹¹Indium(In)-labeled exendin-4 derivative: [Lys¹²(¹¹¹In-BnDTPA-Ahx)]exendin-4. (A) Chemical structure of [Lys¹²(¹¹¹In-BnDTPA-Ahx)]exendin-4. Exendin-4 was labeled with ¹¹¹In via isothiocyanate-benzyl-diethylenetriaminepentaacetic acid (BnDTPA) and 6-aminohexanoic (Ahx) attached to the epsilon amino group at the lysine-12 residue. (B) Representative in vivo axial abdominal image of [Lys¹²(¹¹¹In-BnDTPA-Ahx)]exendin-4 single-photon emission computed tomography (SPECT)/computed tomography (CT) in a mouse. [Lys¹²(¹¹¹In-BnDTPA-Ahx)]exendin-4 successfully visualized the pancreas (white dotted circle). Maximum to minimum SPECT intensity: red > orange > yellow > green > blue > black. R, right; L, left; V, ventral.