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. 2021 Jun 11;9:669354. doi: 10.3389/fcell.2021.669354

TABLE 1A.

Genes specifically enriched in the adult thyroids.

Gene symbol Gene description Function
ART4 ADP-ribosyltransferase 4 (Dombrock blood group) Transport
BHLHE41 Basic helix-loop-helix family member e41 Gene expression
CLIC2 Chloride intracellular channel 2 Channel
CRABP1 Cellular retinoic acid binding protein 1 Signaling
CRYBG3 Crystallin beta-gamma domain containing 3 Cytoskeleton/ECM
DGKI Diacylglycerol kinase iota Signaling
DMRT3 Doublesex and mab-3 related transcription factor 3 Gene expression
EPHA3 EPH receptor A3 Signaling
IGFBPL1 Insulin like growth factor binding protein like 1 Signaling
LRP8 LDL receptor related protein 8 Transport
MPPED2 Metallophosphoesterase domain containing 2 Signaling
MT1F Metallothionein 1F Transport
NEBL Nebulette Cytoskeleton/ECM
OMD Osteomodulin Cytoskeleton/ECM
PDE10A Phosphodiesterase 10A – > inhibition of cAMP signaling? Signaling
RBMS3 RNA binding motif single stranded interacting protein 3 Gene expression.
RNF128 Ring finger protein 128, E3 ubiquitin protein ligase Transport
SCUBE3 Signal peptide, CUB domain and EGF like domain containing 3
SERTM1 Serine rich and transmembrane domain containing 1
SUCNR1 Succinate receptor 1

Top 20 genes regulated in adult thyroids compared to adult tissues mix and not regulated in embryonic thyroids compared to embryonic tissues mix.