TABLE 2.
Top 20 genes differentially regulated in the course of thyroid development as compared to the development of non-thyroid tissues.
| Gene symbol | Description | Function | logFC AT/ET | fdr min | logFC AM/EM | fdr_min |
| ADGRF1 | Adhesion G protein-coupled receptor F1 | Signaling | 3.059 | 5,02E-07 | –0.313 | 0.06 |
| ANXA1 | Annexin A1 | 4.562 | 5.03E-07 | 0.163 | 1 | |
| ANXA9 | Annexin A9 | 3.042 | 5,81E-06 | 0.469 | 1 | |
| ART4 | ADP-ribosyltransferase 4 (Dombrock blood group) | Transport | 3.602 | 6.02E-07 | –0.322 | 1 |
| CCDC85A | Coiled-coil domain containing 85A | 3.276 | 6.88E-06 | –0.450 | 0.01 | |
| CLIC6 | Chloride intracellular channel 6 | Channel | 3.342 | 4,15E-04 | 0.303 | 1 |
| CTGF | Connective tissue growth factor | Signaling. | 3.056 | 1,75E-05 | –0.329 | 1 |
| DAPL1 | Death associated protein like 1 | 4.154 | 5.03E-07 | 0.008 | 1 | |
| DGK1 | Diacylglycerol kinase iota | Signaling | 4.057 | 5.03E-07 | –1.409 | 0.02 |
| DIO1 | Iodothyronine deiodinase 1 | Thyroid hormone | 5.533 | 1.04E-06 | 1.270 | 0.7 |
| ESR1 | Estrogen receptor 1 | Gene expression | 3.667 | 1.77E-05 | –0.637 | 0.001 |
| GPM6A | Glycoprotein M6A | 4.184 | 0.002 | –2.452 | 0.05 | |
| MT1F | Metallothionein 1F | Transport | 3.617 | 6.38E-07 | –1.263 | 0.12 |
| MT1G | Metallothionein 1G | Transport | 3.910 | 1.00E-06 | –1.500 | 0.05 |
| MT1H | Metallothionein 1H | Transport | 3.411 | 1.16E-06 | –1.200 | 0.09 |
| OMD | Osteomodulin | Cytoskeleton/ECM | 3.468 | 5.16E-07 | –0.382 | 1 |
| PKHD1L1 | PKHD1 like 1 | 4.736 | 5.03E-07 | 0.159 | 1 | |
| SCNN1A | Sodium channel epithelial 1 alpha subunit | Channel | 3.378 | 0.003 | –0.934 | 1E-05 |
| TNFRSF11B | TNF receptor superfamily member 11b | Signaling | 6.498 | 5.03E-07 | 0.318 | 1 |
| TPO | Thyroid peroxidase | Thyroid hormone | 5.091 | 5.03E-07 | 0.010 | 1 |
Genes that are regulated in adult thyroids compared to embryonic thyroids, but not in adult tissues mix compared to embryonic tissues mix are listed. logFC AT/ET, log fold change when comparing adult versus embryonic thyroids. logFC AM/EM, log fold change when comparing adult versus embryonic tissues mix. Fdr, false discovery rate.