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Silencing PTPN4 reverses the inhibitory effect of knockdown of miR-16-5p on H/R-induced AC16 cell damage: (a) PYPN4 protein in AC16 cells; (b) LDH levels in AC16 cells; (c) CK-MB levels in AC16 cells; (d) AC16 cell apoptosis level; (e) autophagy-related protein levels in AC16 cells. ∗P < 0.05, ∗ ∗P < 0.01, and ∗ ∗ ∗P < 0.001 vs. the NC group; #P < 0.05 and ##P < 0.01 vs. the sh-NC + H/R group; @P < 0.05, @@P < 0.01, and @@@P < 0.001 vs. the miR-16-5p inhibitor + H/R group.
