Table 1.
Signature mutations of SARS-CoV-2 variants of concern/interest analyzed.
| SARS-CoV-2 lineage | Mutations outside S gene | Mutations in S gene | Mutations covered by Sanger sequencing |
|---|---|---|---|
| B.1.1.7 (alpha) | orf1a:T1001I | S:del69/70 | S:N501Y |
| orf1a:A1708D | S:del144/145 | S:A570D | |
| orf1a:I2230T | S:N501Y | S:D614G | |
| orf1a:del3675/3677 | S:A570D | S:P681H | |
| orf1b:P314L | S:D614G | S:T716I | |
| Orf8:Q27* | S:P681H | ||
| Orf8:R52I | S:T716I | ||
| Orf8:Y73C | S:S982A | ||
| N:D3L | S:D1118H | ||
| N:R203K | |||
| N:G204R | |||
| N:S235F | |||
| B.1.351 (beta) | ORF1a:T265I | S:D80A | S:K417N |
| ORF1a:K1655N | S:D215G | S:E484K | |
| ORF1a:K3353R | S:del241/243 | S:N501Y | |
| ORF1a:del3675/3677 | S:D614G | ||
| ORF1b:P314L | S:A701V | ||
| ORF3a:Q57H | |||
| ORF3a:S171L | |||
| E:P71L | |||
| N:T205I | |||
| P.1 (gamma) | orf1a:S1188L | S:L18F | S:K417T |
| orf1a:K1795Q | S:T20N | S:E484K | |
| orf1a:del3675/3677 | S:P26S | S:N501Y | |
| orf1b:P314L | S:D138Y | S:D614G | |
| orf1b:E1264D | S:R190S | S:H655Y | |
| orf3a:S253P | S:K417T | ||
| orf8:E92K | S:E484K | ||
| N:P80R | S:N501Y | ||
| N:R203K | S:D614G | ||
| N:G204R | S:H655Y | ||
| S:T1027I | |||
| S:V1176F | |||
| P.2 (zeta) | orf1a:L3468V | S:E484K | S:E484K |
| orf1a:L3930F | S:D614G | S:D614G | |
| orf1b:P314L | S:V1176F | ||
| N:A119S | |||
| N:R203K | |||
| N:G204R | |||
| N:M234I | |||
| B.1.617.2 (delta) | ORF1b:P314L | S:T19R | S:L452R |
| ORF1b:G662S | S:del157/158 | S:T478K | |
| ORF1b:P1000L | S:D950N | S:D614G | |
| ORF3a:S26L | S:P681R | ||
| M:I82T | |||
| ORF7a:V82A | |||
| ORF7a:T120I | |||
| ORF8:del119/120 | |||
| N:D63G | |||
| N:R203M | |||
| N:D377Y |