Table 1.

Patient Characteristics, Treatment and Outcome.

Patient number, age, and sex	Autoimmune phenomenon	Time between vaccination and symptom onset	Vaccine dose	Relevant investigations	Treatment(outcome in parenthesis)
1, 49 y/o, Male	Symmetric polyarthritis	3 days	First (Second uneventful under prednisone 10 mg)	•CRP 1.3 mg/dL •Hand radiographs and CXR: Normal •ANA, RF, and parvovirus IgM: Negative •ACPA: Positive	Prednisone 10 mg per day (Resolution of symptoms). Flared upon gradual tapering over 8 weeks, thus methotrexate was added
2, 28 y/o, Male	Left eye panuveitis (Exacerbation of Behçet’s disease)	10 days	First (Second uneventful under prednisone 40 mg)	•Ophthalmologic evaluation •WBC count 12,100/μL, CRP 6 mg/dL, ESR 40 mm/hr •Previously, ANA, RF, c-ANCA, and p-ANCA: Negative	Topical corticosteroids, IV corticosteroids, azathioprine (Resolution of symptoms and normalization of WBC count and CRP levels)
3, 34 y/o, Male	Pericarditis (Recurrence)	1 day	First (Second uneventful under prophylactic NSAIDs)	•WBC count 11,300/μL, CRP 2.75 mg/dL •ECG: Known lateral wall T-wave inversions. •TTE: Mild pericardial effusion •Previously, ANA and RF: Negative	NSAIDs and colchicine (Resolution of symptoms and normalization of WBC count and CRP levels)
4, 60 y/o, Male	Temporal arteritis-like disease	3 days	First (Second uneventful under prednisone 15 mg)	•CRP 8.7 mg/dL, ESR 48 mm/hr •Temporal US and brain CT angiography: Unremarkable •Ophthalmologic evaluation: No AION	Prednisone 20 mg per day (Resolution of symptoms)
5, 60 y/o, Male	FUO	A few hours	Second (First uneventful)	•CRP 29 mg/dL, ESR 70 mm/hr •Negative blood cultures. Negative serology for Brucella, Ricketsia typhi, Coxiella Burnetti , cytomegalovirus, HIV, and Syphilis •Negative PCR for SARS-COV-2 •ANA, RF, c-ANCA, and p-ANCA: Negative •Whole body CT scan –no pathology Temporal US- negative	No specific treatment(Spontaneous clinical resolution; repeat CRP within 2 days declined to 12.4 mg/dL)
6, 37 y/o, Female	Oligoarthritis	3 weeks	Second (First uneventful)	•CRP 0.7 mg/dL	NSAIDs (Resolution of symptoms)
7, 37 y/o, Male	Pericarditis (new-onset)	10 days	First (Second uneventful)	•CRP 0.8 mg/dL •ECG: Normal •TTE: Mild pericardial effusion	NSAIDs and colchicine (Resolution of symptoms)
8, 22 y/oMale	Myocarditis	2 weeks	Second (First uneventful)	•WBC count 12,700/μL, CRP 1.4 mg/dL, Troponin 103 ng/L, CPK 2380 U/L •Negative PCR for SARS-COV-2 •ECG: Diffuse ST elevations and PR depressions •TTE: Unremarkable	NSAIDs and colchicine (Resolution of symptoms and normalization of WBC count, CRP, CPK, and troponin levels)

Abbreviations: (reference range where relevant): ACPA, anti-citrullinated protein antibodies; AION, anterior ischemic optic neuropathy; ANA, antinuclear antibodies; ANCA, anti-neutrophil cytoplasmic antibody; c-ANCA, cytoplasmic ANCA; CRP, C-reactive protein (0–0.5 mg/dL); CT, computed tomography; CXR, chest X-ray; CMV, cytomegalovirus; ECG, electrocardiograph; ESR, erythrocyte sedimentation rate (0–20 mm/hr); FUO, fever of unknown origin; HIV, human immunodeficiency virus; NSAIDs, non-steroidal anti-inflammatory drugs; p-ANCA, perinuclear ANCA; PCR, polymerase chain reaction; RF, rheumatoid factor; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2; TTE, transthoracic echocardiography; US, ultrasound; WBC, white blood cells(3.79–10.33 cells/μL; y/o, year-old; CPK creatine phosphokinase (46–161 U/L)