Figure 2.

Lung pathology of SARS-CoV-2-infected mice treated with RDV and vehicle prophylactically and therapeutically

Pathologic features of acute lung injury (ALI) were scored using two separate tools: the American Thoracic Society Lung Injury Scoring (ATS ALI) and the diffuse alveolar damage (DAD) system. Using these systems, we created an aggregate score for the following features: neutrophils in the alveolar and interstitial space, hyaline membranes, proteinaceous debris filling the air spaces, and alveolar septal thickening. Three randomly chosen high-power (×60) fields of diseased lung were assessed per mouse. Representative images are shown from vehicle- and RDV-treated mice. Symbols identifying example features of disease are indicated in the figure. All images were taken at the same magnification. Scale bars indicate 100 μm.