REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
C144_LS	Dr. Michel Nussenzweig, The Rockefeller University	N/A
C135_LS	Dr. Michel Nussenzweig, The Rockefeller University	N/A
3BNC117_LS	Dr. Michel Nussenzweig, The Rockefeller University	N/A
10-1074_LS	Dr. Michel Nussenzweig, The Rockefeller University	N/A
Bacterial and virus strains
SARS-CoV-2 mouse-adapted 10 (MA10)	Dr. Ralph Baric, UNC Chapel Hill	N/A
SARS-CoV-2 MA10 B.1.351 spike	This paper	N/A
Chemicals, peptides, and recombinant proteins
Remdesivir	Gilead Sciences	GS-5734 (RDV)
Vehicle [12% sulfobutylether-β-cyclodextrin in water (with HCl/NaOH) at pH 5]	Gilead Sciences	N/A
Critical commercial assays
mMESSAGE mMACHINE T7 Transcription Kit	ThermoFisher Scientific	AM1344
Experimental models: Cell lines
Vero C1008 (E6)	ATCC	CRL-1586
Experimental models: Organisms/strains
C57BL/6 Ces1c/ mice	Jackson Labs	Stock # 014096
C57BL/6J	Jackson Labs	Stock # 000664
BALB/c	Envigo	# 047
Oligonucleotides
E gene forward primer: 5′ CGATCT CTTGTAGATCTGTTCTCE 3′	Integrated DNA Technologies	N/A
E gene reverse primer: 5′ ATATT GCAGCAGT ACGCACACA 3′	Integrated DNA Technologies	N/A
N gene forward primer: 5′ CGATC TCTTGTAGATCTGTTCTC 3′	Integrated DNA Technologies	N/A
N gene reverse primer: 5′ GGTGAA CCAAGACGCAGTAT 3′	Integrated DNA Technologies	N/A
Software and algorithms
Prism 9	GraphPad	https://www.graphpad.com/scientific-software/prism/