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. 2021 Jun 7;53(7):1075–1087. doi: 10.1038/s41588-021-00878-z

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 5 — a, TADs of stage 13 embryos clustered on directionality index. Cluster 2 is further divided into five sub-clusters with an equal number of TADs. b, CTCF ChIP-seq signal across TAD borders in each cluster. c, Rad21 ChIP-seq signal across TAD borders in each cluster. d, Intra-domain directionality index was calculated and was used to cluster TADs into three groups. There are 1,221, 1,636 and 1,303 TADs in clusters 1, 2 and 3, respectively. Note the low DI values on the y-axis. e, Average directionality index across borders of all TADs without clustering. TADs are arranged with DI of decreasing absolute value on the 5′ border and DI of increasing absolute value on the 3′ border. f, Relative enrichment of CTCF across borders of all TADs showing indistinguishable differences in signal strength at borders on both sides of TADs. g, Relative enrichment of Rad21 across borders of all TAD showing indistinguishable differences in signal strength at borders on both sides of TADs. Data in e, f, and g are represented as mean±SEM. h, Density of TSS across three clusters of TAD borders. i, RNA level across the borders of three clusters of TADs. Data in h and i are represented as mean±SEM. j, Percentage of loops and ordinary domains in clusters 1&3 and cluster 2.