Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Jun 7;53(7):1075–1087. doi: 10.1038/s41588-021-00878-z

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 2 — a, Schematic representation of the ten developmental stages examined by in situ Hi-C. b, Chromatin interaction frequency mapped at a 5-kb resolution. c, Clusters of TAD borders appear for ordinary domains (light blue), loop domains (red) and non-domains (black) at each specific developmental stage. ‘Non-domain border’ refers to a genomic region not identified as a TAD border at a specific embryonic developmental stage, which switches to a TAD border at other development stages. d, Heatmaps of aggregated TADs for the eight developmental stages. The interaction frequency of aggregated TADs from s10 to s23 was normalized against s9. Three phases of change in the TAD structure are shown below, with the developmental stages also shown (TAD number at s9, s10, s11, s12, s13, s15, s17 and s23: 2,471, 2,805, 3,599, 4,036, 4,160, 3,164, 3,609 and 3,199).