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. 2021 Jun 7;53(7):1075–1087. doi: 10.1038/s41588-021-00878-z

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — a, Heatmaps of chromosome 2 plotted at a 50-kb resolution at multiple developmental stages. b, Hi-C matrices (observed/expected) for chromosome 2 at a 50-kb resolution at multiple developmental stages. c, Hi-C matrices (observed/expected) of an example region between 0 and 50 Mb in chromosome 2. d, Chromatin switched between A and B compartments during embryo development. e, PCA of compartment scores derived from adjusted Cscore values of Hi-C matrices at multiple developmental stages.