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. 2021 Feb 13;31(8):5851–5862. doi: 10.1007/s00330-021-07716-0

Table 3.

Univariate and multivariate analysis of prognostic factors of OS in 135 patients with malignant biliary obstruction

Univariate analysis Multivariate analysis
Variable* No. of cases Median OS (95%CI)* p HR (95%CI) p$
Gender Male 82 10.5 (9.4–11.6) 0.789
Female 53 11.6 (9.9–13.3)
Age (year) ≥ 65 56 10.6 (9.1–12.1) 0.973
< 65 79 11.4 (9.9–12.9)
EGCO PS + ≥ 2 48 9.9 (7.7–12.1) 0.159
< 2 87 11.8 (10.1–13.5)
Bismuth type ‡ III–IV 31 7.6 (6.0–9.2) 0.000 2.778 (1.765, 4.371) 0.000
I–II 104 12.1 (10.3–13.9)
Distant metastasis Yes 58 10.3 (9.2–11.4) 0.021 1.708 (1.171, 2.491) 0.005
No 77 11.8 (10.5–13.1)
CA 125 (U/mL) > 40 71 10.6 (9.0–12.2) 0.976
≤ 40 64 11.4 (10.1–12.7)
CA 19-9 (U/mL) > 40 118 10.9 (9.9–11.9) 0.190
≤ 40 17 9.1 (4.4–13.8)
Length of stricture (cm) ≥ 4 60 9.1 (8.0–10.3) 0.000 1.727 (1.124, 2.654) 0.013
< 4 75 13.4 (11.1–15.7)
Length of stent (mm) > 6 48 10.2 (8.2–12.2) 0.379
≤ 6 87 11.6 (9.9–13.3)
Stent placement Following 57 10.9 (9.5–12.3) 0.365
Synchronising 78 10.7 (9.2–12.2)

*OS data are in months, and the Kaplan–Meier method was used

The long-rank test was used

$Cox regression was used

+According to the Toxicity and response criteria of the Eastern Cooperative Oncology Group

According to the Bismuth classification of perihilar cholangiocarcinoma

OS, overall survival; CA125/19-9, carbohydrate antigen 125/19-9