Fig. 6.

p300 expression is negatively associated with Rbbp7 in PS19 mice and human MTG neurons. a, b High magnification representative photomicrographs of hippocampal sections stained for GFP and p300. c, d Linear correlation of GFP and p300 in CA1 of the hippocampus for the PS19 AAV-GFP and PS19 AAV-Rbbp7 mice. e p300 mRNA expression is significantly elevated in laser-captured neurons from the MTG of AD patients. f Neuronal p300 mRNA expression is negatively correlated to Rbbp7 mRNA expression. Box plots: center line represents the median, the limits represent the 25th and 75th percentile, and the whiskers represent the minimum and maximum values of the distribution. **p < 0.01