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. 2021 Feb 18;31(8):5689–5698. doi: 10.1007/s00330-021-07703-5

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Flowchart of the study. ^aExcluded for incomplete data or inconclusive cytology or sub-centimetric size (fine-needle aspiration is rarely indicated by any TIRADS for the latter). ^bIndeterminate cytology: of those, 283 were classified as Thy3, according to the British Cytological classification (before 2014), and, later on, 596 ones as TIR3A (370) and TIR3B (226), according to the SIAPEC-IAP classification. Ø = size of the lesion