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. 2021 Jul 9;7:91. doi: 10.1038/s41523-021-00300-1

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — a Box-and-whisker plot was generated to show the expression of JAB1 in breast tumor subtypes. Statistical analysis was performed using GraphPad Prime 7.0 with unpaired t test (two-tailed). b, c JAB1 expression is inversely correlated with breast cancer patient overall (b) and recurrence-free survival (c). d JAB1 expression is inversely correlated with TNBC patient overall survival. e, f BT549 or MDA-MB-231 cells were treated with 30 nM JAB1 siRNAs (siJAB1-1, siJAB1-2), scrambled siRNA control for 3 days or 5 µM SB203580 for 1 day followed by MTT assay to analyze cell growth (e) or Matrigel invasion assay to determine in vitro invasion (f). Data are means ± SD from three experiments. *P < 0.01 vs Control. #P < 0.05.