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. 2021 Jul 9;11:14186. doi: 10.1038/s41598-021-93616-8

Figure 4.

Figure 4

The gene expression profiles in miR-378a suppressed NHEK cells. (a) Heatmap of DEGs in keratinocytes with miR-378a suppressing for 24 h (186 genes with |log(fold-change)| > 1; left) and 48 h (160 genes with |log(fold-change)| > 1.5; right). The heatmaps were drawn using ComplexHeatmap R package. (b) The top overlapped KEGG pathways associated with up- and down-regulated genes at both 24 h and 48 h post-transfection of miR-378a inhibitor. The figures were drawn using tidyverse R package.