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. 2021 Jul 9;11:14220. doi: 10.1038/s41598-021-93621-x

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Surrogate parameters for cardiac preload and afterload. (A) Global end-diastolic volume index (GEDI) and (B) intrathoracic blood volume index as surrogate parameters for cardiac preload were determined using the PiCCO System before and 0.5, 3, and 6 h after ROSC to investigate changes in diastolic volume filling and diastolic function after cardiac arrest (CA) and levosimendan treatment. (C) To determine the influence on cardiac afterload, systemic vascular resistance index (SVRI) was recorded. CA and levosimendan did not influence any parameter at the selected time points. BL baseline, VEH vehicle, LEVO levosimendan. Statistics: repeated measures two-way ANOVA, followed by Šidák’s multiple comparisons test; data are presented as means ± SD.